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Srinivasa Rao, Y.
- Method Development and Validation for Quantitative Analysis of Aspirin and Simvastatin in Pharmaceuticals by RP- HPLC
Abstract Views :201 |
PDF Views:77
Authors
Affiliations
1 Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram, Guntur-522 019 (A.P.), IN
2 Chebrolu Hanumaiah institute of Pharmaceutical sciences, Chandramoulipuram, Chowdavaram, Guntur-522 019 (A.P.), IN
3 Alkem Research Center, Industrial Estate, Opposite Talons Police Station, Navi Mumbai - 410 208, Maharashtra, IN
4 Vignan Institute of Pharmaceutical Technology, Duvvada, Visakhapatnam - 530 046, (A.P.), IN
1 Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram, Guntur-522 019 (A.P.), IN
2 Chebrolu Hanumaiah institute of Pharmaceutical sciences, Chandramoulipuram, Chowdavaram, Guntur-522 019 (A.P.), IN
3 Alkem Research Center, Industrial Estate, Opposite Talons Police Station, Navi Mumbai - 410 208, Maharashtra, IN
4 Vignan Institute of Pharmaceutical Technology, Duvvada, Visakhapatnam - 530 046, (A.P.), IN
Source
Journal of Pharmaceutical Research, Vol 11, No 4 (2012), Pagination: 132-135Abstract
A simple, accurate and precise reverse phase high performance liquid chromatography (RPHPLC) method has been developed and validated for the simultaneous determination of aspirin and simvastatin in combined dosage form. Separation was performed on a C18 column [ODS column, 250mm × 4.5mm with particle size 5μm. with a mobile phase consisting of acetonitrile: methanol: phosphate buffer (55:30:15) at a flow rate of 1ml/min and UV detection was carried out at 225nm. The developed method was validated for the parameters like system suitability, specificity, linearity, accuracy and robustness according to the ICH guidelines Q2B. Retention times of aspirin and simvastatin were found to be 3.4 and 7.44 respectively. Linearity was found in the range from 10-50μg/mL for aspirin and 2-10μg/mL for simvastatin with correlation coefficients 0.9998 and 0.9999 respectively. The % recovery for 100% spiked level was 99.44 and 101.20 for aspirin and simvastatin respectively. The developed method was accurate, robust, selective, linear and repeatable which could be used for routine analysis of aspirin and simvastatin in their combined dosage forms.Keywords
Aspirin, Simvastatin, Simultaneous, RP-HPLC.Full Text
- Pyroxene Exsolution Textures in Plutonic Basic Igneous Rocks from Kandra Igneous Complex, Nellore Schist Belt, Andhra Pradesh
Abstract Views :190 |
PDF Views:133
Authors
Affiliations
1 Department of Geology, Andhra University, Visakhapatnam - 530 003, IN
1 Department of Geology, Andhra University, Visakhapatnam - 530 003, IN
Source
Journal of Geological Society of India (Online archive from Vol 1 to Vol 78), Vol 63, No 3 (2004), Pagination: 337-340Abstract
No Abstract.Full Text
- 3D Construction of Tumour in Magnetic Resonance Imaging Slices
Abstract Views :329 |
PDF Views:4
Authors
Affiliations
1 Aditya Institute of Technology and Management, Tekkali, IN
1 Aditya Institute of Technology and Management, Tekkali, IN
Source
Digital Image Processing, Vol 8, No 9 (2016), Pagination: 287-291Abstract
The World Health Organization (WHO) reports reveal that cancer deaths have been increasing day by day in India. Therefore, cancer detection is a challenging task to the doctors to detect it, in the preliminary stages with the help of Magnetic Resonance Imaging (MRI). In this paper, first the MRI image stack is preprocessed and a new Hybrid algorithm based on Expectation-Maximization, Histogram and object based thresholding methods is developed to identify the cancer. The resultant of the algorithm is in 2D format. For better understanding of the cancer stage these 2D images are combined to form a 3D view of the cancer. The performance of these hybrid fused techniques will be compared in terms of quality of the resultant tumor. The proposed work will be implemented using MATLAB R2015a.
Keywords
Tumor, MRI, Segmentation, Expectation-Maximization, 3D Modeling.
- A Review on Extrusion-Spheronisation
Abstract Views :215 |
PDF Views:3
Authors
Affiliations
1 Vignan Institute of Pharmaceutical Technology, Visakhapatnam, IN
1 Vignan Institute of Pharmaceutical Technology, Visakhapatnam, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 5 (2017), Pagination: 1502-1508Abstract
Pellets, being multiple unit-dosage forms, are widely used as they offer both manufacturing and therapeutic advantages over single-unit solid dosage forms. There are various techniques to manufacture pellets. Extrusion/ Spheronisation or maramuerization is a rapid, flexible and a multi-step process capable of making uniformly sized spherical particles commonly referred to as spheres or pellets of diameter ranging from about 0.5mm to 10mm. It is a best method as it has an advantage of excellent product flowability, easy scale-up, high yield, narrow particle size distribution, excellent process repeatability. Various techniques used to produce pellets, steps involved, equipments used, effect of process variables involved in extrusion spheronisation process, evaluation parameters and properties requirement of final pellets produced are covered in review. We highlighted the effect of process variables on final quality of pellet.Keywords
Various Techniques, Spheronisation Steps, Process Variables, Evaluation.- Formulation and In Vivo Evaluation of Granisetron HCI Mouth Dissolving Films in Healthy Human Volunteers
Abstract Views :191 |
PDF Views:0
Authors
Affiliations
1 Acharya Nagarjuna University, Nagarjuna nagar, Guntur-522 510, A.P, IN
2 Vignan Institute of Pharmaceutical Technology, Visakhapatnam-5000049, A.P, IN
1 Acharya Nagarjuna University, Nagarjuna nagar, Guntur-522 510, A.P, IN
2 Vignan Institute of Pharmaceutical Technology, Visakhapatnam-5000049, A.P, IN
Source
Research Journal of Pharmacy and Technology, Vol 11, No 1 (2018), Pagination: 236-244Abstract
Fast dissolving drug delivery systems such as mouth dissolving films (MDF) are novel dosage forms that disintegrate or dissolve within the oral cavity and it is considered the most convenient, easy, safest route of administration. Present work aimed at preparing quick onset of action of Graniserton HCl which is beneficial in emesis, aiding in the enhancement of bioavailability and is very convenient for administration without the problem of swallowing and using water. Present mouth dissolving films were prepared by the solvent-casting method using a combination of different polymers, HPMC E3, HPMC E5 and HPMC E15, along with Propylene glycol as a plasticizer. Mouth dissolving films were evaluated for physical characteristics such as thickness, folding endurance, drug content, surface pH, percentage elongation and tensile strength and results were found to be satisfactory. The Fourier-transform infrared study and scanning electron microscopy for the drug-polymer interaction was carried out. The formulations were subjected to disintegration, in-vitro drug release test. The in vitro disintegration time of the optimized batch F14 was found to be 9 sec and drug release was found to be very fast i.e. 99.69±6.27% of within 7min. In vitro and in vivo evaluation of the films confirmed their potential as an innovative dosage form to improve bioavailability and quick onset of action of Graniserton HCl in the management of chemotherapy induced vomitings.Keywords
Graniserton HCI, Mouth Dissolving Films, Solvent-Casting Method, HPMC, Human Volunteers.References
- Ravi Kumar K, Mercy S.M. Fast dissolving films: A unique strategy for drug delivery. Asian J. Pharm. Res, 4; 2014:7-55.
- Smart J. D. Buccal drug delivery, Expert Opin. Drug Deliv. 2; 2005: 507–517.
- Lindgren S, Janzon L. Prevalence of swallowing complaints and clinical findings among 50-79-year-old men and women in an urban population. Dysphagia. 6; 1991: 187-192.
- Ciper M, Bodmeier R. Modified conventional hard gelatin capsules as fast disintegrating dosage form in the oral cavity. Eur. J. Pharm. Bio pharm. 62(2); 2006: 178- 184.
- Mizumoto T, Masuda Y, Yamamoto T, Yonemochi E, Terada K. Formulation design of a novel fast disintegrating tablet. Int. J. Pharm, 2005; 306: 83-90.
- Seager H. Drug delivery products and the Zydis fast dissolving dosage form. J. Pharm. Pharmacol. 50(4); 1998: 375-82.
- Sastry S.V, Nyshadham J.R, Fix J.A. Recent technological advance in oral drug delivery: A review. Pharm. Sci. Technol. Today, 3 (4); 2000: 138-145.
- Biraju patel, Dhaval patel, Ramesh parmar, Chirag patel, Tejaserasiya, Sanja S.D. Development and in vitro evaluation of fast dissolving tablet of Glipizide. Int. J. Pharmacy and pharmaceuticals. 1; 2000: 145-150.
- Tintinalli, Judith E. 2010. Emergency Medicine: A Comprehensive Study Guide (Emergency Medicine (Tintinalli). New York: McGraw-Hill Companies.
- Kumar G.V, Krishna R.V, William G.J, Konde A. Formulation and evaluation of buccal films of salbutamol sulphate. Indian J Pharm Sci. 67; 2005:160–164.
- Mona N, Mayank N, Vikram C. Formulation and evaluation of mouth dissolving film of antipsychotic drug aripiprazole. Der Pharmacia Lettre. 4(4) ; 2012: 1221-1227.
- Prabhakara P, Ravi M, Marina K, Vijaynarayana K, Ullas Souza D, Harish N.M, Shastry C.S. Formulation and evaluation of fast dissolving films of levocetirizine dihydrochloride. Int J Pharm Inves. 1(2); 2011: 99–104.
- Apoorva M, Neha Chhabra, Geeta Aggarwal. Formulation and characterization of fast dissolving buccal films. Der Pharmacia Lett. 3(1); 2011:152-165.
- Dinge A, Nagarsenker M. Formulation and evaluation of fast dissolving films for delivery of triclosan to the oral cavity. AAPS Pharm Sci Tech, 9(2); 2012: 349-56.
- Bhupinder Bhyan, Sarita Jangra, Mandeep Kaur, and Harmanpreet Singh. Orally Fast Dissolving films: Innovation in formulation and technology. Int J of Pharm Sci review and res, 9(2); 2010: 50-57.
- Shivani Singh, Satyam Gangwar, Garima Garg, Vipin Garg and P. K. Sharma. Formulation and evaluation of rapidly disintegrating film of Levocetrizine Hydrochloride. Der Pharmacia Lettre. 2(2); 2010: 434-439.
- Peh KK, Wong FC. Polymeric films as vehicle for buccal Delivery: Swelling, mechanical and bioadhesive properties. J Pharm Sci. 2; 1999:53-61.
- Agarwal GP, Seth AK, Saini TR. Evaluation of free films. Indian Drugs, 23; 1985:45-7.
- Tanwar YS, Chauhan CS, Sharma A. Development and evaluation of carvedilol transdermal patches. Acta Pharm, 57; 2007:151-59.
- Chen M, Tirol G, Schmitt R, Chien C, Dualeh A. Film forming polymers in fast dissolve oral films. AAPS Annual meetings-posters and papers, T3200, 2006.
- Cilurzo F, Cupone IE, Minghetti P, Selmin F, Montanari L. Fast dissolving films made of maltodextrins. Eur J Pharmaceut and Biopharmaceut. 70; 2008:895–900.
- Ivory AA, Rossman JM, Lee KM. Rapidly dissolving edible film compositions with cellulose film forming polymers. United States Patent application publication,2004:1-9
- Kai Bin Liew, Yvonne Tze Fung Tan, and Kok Khiang Peh. Characterization of Oral Disintegrating Film Containing Donepezil for Alzheimer Disease. AAPS PharmSciTech. 13 (1); 2012: 134-142.
- Aditya D, Mangal N. Formulation and Evaluation of Fast Dissolving Films for Delivery of Triclosan to the Oral Cavity. AAPS PharmSciTech. 9; 2009: 349.